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一方面，拓展CIN3适应症，替代部分手术治疗。CIN3属于高级别癌前病变，当前以手术治疗为主，但我国CIN3患者HPV感染率高达84.37%，部分无法耐受手术、高龄或有强烈生育需求的患者，存在迫切的无创治疗诉求。而APL-1702的国际多中心Ⅲ期研究中，CIN3患者亚组的病理消退率达到37.6%，远高于安慰剂组的28.4%。未来若获批，其将承接这部分强治疗需求，成为手术治疗外的优选项。
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